Abstract #4517

Simultaneous quantitative susceptibility, PDFF and transversal relaxation time mapping in dystrophic skeletal muscle

Benjamin Leporq^1,2, Arnaud Le Troter³, Yann Le fur³, Emmanuelle Salort-Campana⁴, Maxime Guye³, Olivier Beuf², and David Bendahan^3,5

¹Center of Research on inflammation; Inserm U1149, Université Paris Diderot, Paris, France, ²CREATIS CNRS UMR 5220; Inserm U1044, Université de Lyon, Villeurbanne, France, ³CRMBM; CNRS UMR 7339, Aix-Marseille University, Marseille, France, ⁴Genetique Médicale et Génomique Fonctionelle; Inserm UMR S_910, Aix Marseille University, Marseille, France, ⁵CEMEREM, Hopital de la Timone, Pôle d’imagerie médicale, AP-HM, Marseille, France

We have developed a dedicated algorithm allowing to quantify, from a single MR acquisition fat and muscle fractions together with magnetic susceptibility and transverse relaxation time (T2*). This approach was linked to a dedicated segmentation algorithm allowing to quantify specific indices which could be of interest for the assessment of disease severity and progression. Our results showed the feasibility of quantitative susceptibility mapping (QSM) in thigh muscles and demonstrated that its implementation into the fat-water separation reconstruction pipeline is possible. For dystrophies assessment, magnetic susceptibility-related information might provide a useful supplementary materials in comparison to relaxometry and fat fraction measurements.

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