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Abstract #0018

Towards in vivo spinal cord cyto- and myelo-architecture deciphering using multi-modal MRI parcellation at 7T

Manuel Taso1,2,3, Aurélien Massire1,2,3, Pierre Besson1,2, Arnaud Le Troter1,2, Maxime Guye1,2, Jean-Philippe Ranjeva1,2,3, and Virginie Callot1,2,3

1CRMBM, Aix-Marseille Univ, CNRS, Marseille, France, 2Pôle d'imagerie médicale, Hôpital de la Timone, CEMEREM, AP-HM, Marseille, France, 3iLab-Spine international associate laboratory, Marseille/Montréal, France

Ultra-high-field MRI offers exciting perspectives for the in vivo structural characterization of central nervous system tissues. Based on high-resolution multi-parametric imaging at 7T, this preliminary work focuses on the generation of new spinal cord (SC) templates, hence proposing a high-resolution T2*-w MR average with exquisite anatomical details. Parcellation of the SC substructures into individual WM tracts and motoneurone clusters was also investigated using classification methods and multimodal data (T1/T2*/DTI). Preliminary promising results revealed some insights in the underlying SC cyto- and myelo-architecture. Future developments will extend to the whole cervical cord, holding tremendous promises for studying more specific pathophysiological impairments.

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