Cognitive impairment (CI) is a major manifestation of multiple sclerosis (MS) and is responsible for extensively hindering patient quality of life.1 Cortical gray matter damage is critical to CI, but is poorly characterized by conventional MRI. We employed advanced methods by evaluating SIR-qMT-derived indices for differences between MS patients and healthy volunteers at 7T and derived associations with neuropsychological measures of cognitive impairment. We found significant reduction in kmf in cGM of MS patients, unique association with EDSS score, and strong correlation with cognitive performance indicating that kmf may be a significant biomarker of GM damage in MS.
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