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Abstract #0023

Individualized Tractography-Based Parcellation of the Globus Pallidus Pars Interna using 7T MRI in patients with Parkinson’s Disease Prior to DBS Surgery

Rémi Patriat1, Yuval Duchin1, Christophe Lenglet1, Joshua Aman2, Scott Cooper2, Jerrold Vitek2, and Noam Harel1

1CMRR / Radiology, University of Minnesota, Minneapolis, MN, United States, 2Neurology, University of Minnesota, Minneapolis, MN, United States

The success of deep brain stimulation (DBS) surgeries for Parkinson’s disease relies on the accurate placement of an electrode within the motor portion of subcortical brain targets. We use 7T MR-tractography to visualize the functional territories of the Globus Pallidus pars Interna. We found that the motor territory is located immediately posteromedially to the associative and limbic territories, akin to the subthalamic nucleus organization. This pattern was reproducible across two DBS patients. These findings shed new light on the functional organization of DBS targets, showing potential for providing valuable information to clinicians for targeting decisions and ultimately enhancing patient’s outcomes.

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