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Abstract #0024

Assessment of cerebral vascular abnormalities in Huntington’s Disease at 7Tesla

Richard J Dury1, Sarah L Mason2, Francesca Cicchetti3, Janelle Drouin-Ouellet2, Roger A Barker2, Penny A Gowland1, and Susan T Francis1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom, 3Département de Psychiatrie & Neurosciences, Université Laval, QC, Canada

Huntington’s Disease (HD) is associated with vascular abnormalities and breakdown in the blood-brain barrier (BBB). Here, we use high spatial resolution time-of-flight magnetic resonance angiography (TOF-MRA) and arterial spin labelling (ASL) to assess vascular abnormalities in HD patients. We develop a pipeline to estimate vessel radii and distribution from TOF-MRA data. A significant decrease in the fractional vessel volume and a higher frequency of narrow vessels (0.15-0.45mm radius) was evident in HD patients compared to healthy volunteers across a number of cortical areas. No significant difference was found in cortical perfusion between the HD patients and healthy volunteers.

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