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Abstract #0035

PET/MR Imaging of Metabolic Bone Activity in Osteoarthritis

Feliks Kogan1, Audrey Fan1, Emily McWalter2, Uchechukwuka Monu1, Edwin Oei3, Andrew Quon1, and Garry Gold1,4,5

1Radiology, Stanford University, Stanford, CA, United States, 22Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada, 3Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands, 4Department of Bioengineering, Stanford University, Stanford, CA, United States, 5Department of Orthopaedic Surgery, Stanford University, San Francisco, CA, United States

Osteoarthritis (OA) is a leading cause of disability, resulting in reduced quality of life, at tremendous societal cost. New hybrid PET/MR systems allow for simultaneous, sensitive, and quantitative assessments of early bone activity in OA with PET, which can be correlated with high-resolution quantitative MR methods of soft tissues to study the pathogenesis of OA. We demonstrate promising initial results of simultaneous PET/MR hybrid imaging of knee OA. Results suggest that PET/MR may detect metabolic abnormalities in subchondral bone, which appear normal on MRI. These advancements will allow us to detect and track early and reversible changes in OA.

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