A major focus in cardiac research is the assessment of myocardial pathology using quantitative T1 mapping. A number of sequences are being investigated for this task. One candidate is MOLLI. It provides superior precision to other cardiac T1 mapping techniques. However, its precision is dependent on heart rate and range of T1 values present. Current attempts at optimizing precision are somewhat impractical, as they utilize separate MOLLI protocols for different heart rates, and for pre/post contrast imaging. This study identifies a single MOLLI protocol optimal for precision over a broad range of heart rates and pre/post contrast T1 values.