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Abstract #0056

White matter changes and correlations with cognitive functions in semi-acute mild traumatic brain injury (mTBI): A hybrid diffusion imaging study

Sourajit Mitra Mustafi1, Chandana Kodiweera2, Jaroslaw Harezlak3, Laura A Flashman4, Thomas W McAllister5, and Yu-Chien Wu1

1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Department of Psychological and Brain Sciences, Dartmouth College, Lebanon, NH, United States, 3Department of Biostatistics, Indiana University, Indianapolis, IN, United States, 4Department of Psychiatry, Dartmouth Hitchcock Medical Center and New Hampshire Hospital, Lebanon, NH, United States, 5Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States

In the present study, we used multi-shell Hybrid Diffusion Imaging (HYDI) to study changes in white matter after mild traumatic brain injury (mTBI). From HYDI data, an array of diffusion metrics was computed including diffusion tensor imaging (DTI), neurite orientation distribution and density (NODDI), and return-to-origin (P0) of the q-space analysis. We study between group differences in diffusion metrics and within-group correlations with outcomes of cognitive functions. In addition, we tested the group effects (i.e., interaction or moderation) on the correlations between diffusion metrics and cognitive functions.

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