Accurate identification of the Optic Radiations (OR) in vivo has great clinical significance in pre-surgical planning. Yet traditional tractography algorithms based on diffusion MRI often fail to recover the full extent of the OR. Post-mortem histology studies show that the OR has a consistent signature of high myelination compared to adjacent white matter tracts. We therefore propose to use quantitative T1-mapping, which is sensitive to myelin, to eliminate candidate fascicles with highly variable T1 profiles. We introduce a fully automatic novel framework that integrates diffusion MRI with T1-mapping, and use it to reconstruct the OR in 62 healthy subjects.
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