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Abstract #0061

Microstructure-Informed Tractography of the Human Optic Radiation In Vivo

Roey Schurr1, Yiran Duan2, Anthony M. Norcia2, Shumpei Ogawa3,4, Jason D. Yeatman5, and Aviv Mezer1

1Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel, 2Department of Psychology, Stanford University, CA, United States, 3Department of Ophthalmology, Atsugi City Hospital, Kanagawa, Japan, 4Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan, 5Department of Speech & Hearing Sciences, University of Washington, Seattle, WA, United States

Accurate identification of the Optic Radiations (OR) in vivo has great clinical significance in pre-surgical planning. Yet traditional tractography algorithms based on diffusion MRI often fail to recover the full extent of the OR. Post-mortem histology studies show that the OR has a consistent signature of high myelination compared to adjacent white matter tracts. We therefore propose to use quantitative T1-mapping, which is sensitive to myelin, to eliminate candidate fascicles with highly variable T1 profiles. We introduce a fully automatic novel framework that integrates diffusion MRI with T1-mapping, and use it to reconstruct the OR in 62 healthy subjects.

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