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Abstract #0062

Using diffusion MRI and tractography to identify macaque vertical occipital fasciculus

Hiromasa Takemura1,2, Franco Pestilli3, Kevin S Weiner4, Georgios A Keliris5,6, Sofia M Landi7, Julia Sliwa7, Frank Q Ye8, Michael A Barnett4, David A Leopold8, Winrich A Freiwald7, Nikos K Logothetis5, and Brian A Wandell4

1Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, Suita-shi, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Suita-shi, Japan, 3Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States, 4Department of Psychology, Stanford University, Stanford, CA, United States, 5Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 6Department of Biomedical Science, University of Antwerp, Antwerp, Belgium, 7The Rockefeller University, New York, NY, United States, 8Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, National Institutes of Health, Bethesda, MD, United States

We evaluated the ability of diffusion MRI-based tractography to identify macaque vertical occipital fasciculus (VOF), an important but little-studied white-matter tract connecting dorsal and ventral visual cortex. We analyzed four macaque diffusion MRI datasets with different resolution. The high-resolution post-mortem dataset reliably detects the macaque VOF, in a consistent manner with previous invasive anatomical studies. Lower resolution in vivo data showed qualitatively consistent results, but the estimated tract endpoints are restricted to sulcus. Taken together, our results demonstrate that the need for high-resolution diffusion MRI to identify certain critical white matter tracts.

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Abstract