Abstract #0063

Impact of acquisition strategies and spherical deconvolution algorithms on brain connectivity mapping in early multiple sclerosis

Carmen Tur¹, Francesco Grussu¹, Ferran Prados^1,2, Thalis Charalambous¹, Sara Collorone¹, Niamh Cawley¹, Baris Kanber^1,2, Daniel R. Altmann^1,3, Sébastien Ourselin^1,4, Frederik Barkhof^1,5, Jonathan D. Clayden⁶, Ahmed T. Toosy¹, Claudia A.M. Gandini Wheeler-Kingshott^1,7,8, and Olga Ciccarelli¹

¹UCL Institute of Neurology, Queen Square MS Centre, UCL, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom, ³London School of Hygiene and Tropical Medicine, Medical Statistics Department, University of London, London, United Kingdom, ⁴Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, United Kingdom, ⁵Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands, ⁶UCL GOS Institute of Child Health, UCL, London, United Kingdom, ⁷Department of Brain and Behavioural Sciences, University of Pavia, Italy, ⁸Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Italy

Multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) allows precise white matter tract reconstructions in healthy brains. However, its implications for connectivity mapping in multiple sclerosis (MS) are unknown. Here we compare MSMT-CSD versus single-shell single-tissue (SSST)-CSD algorithms over different clinically-feasible diffusion-weighted protocols regarding their ability to reconstruct connectivity metrics that distinguish patients with a first inflammatory-demyelinating episode (n=19) from controls (n=12). Methodical analysis of data from time- and directionality-matched protocols showed that a greater angular resolution improves results and is preferable to choosing multi-tissue-CSD algorithms. Given similar angular resolution, all algorithms perform similarly, producing highly reproducible brain connectivity metrics.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.