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Abstract #0073

Robust VFA relaxometry by Continuous Saturation of Magnetization Transfer (CSMT) effects with Non-selective Multi-Band pulses.

Rui Pedro A. G. Teixeira1,2, Anthony N. Price1,2, Ana A. Baburamani1, Shaihan J. Malik1, and Joseph V. Hajnal1,2

1Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 2Centre for the Developing Brain, King's College London, London, United Kingdom

Variable Flip Angle (VFA) relaxometry methods have recently been shown to be sensitive to magnetization transfer (MT) induced bias. Common description of this effect relies on a two-pool model (restricted macromolecular pool & visible free water pool). Current practice to restrict influence of MT consists in stretching of RF pulse durations in order to minimize/counter-balance the effect of macromolecular exchange for different flip angle measurements. This work proposes to minimize the estimation bias by using constant saturation MT pulses that simultaneously excite the free-water pool and saturate the restricted-pool creating constant RF-saturation conditions independently of the flip angle (FA) applied.

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