Abstract #0074

Mitigating the Effect of Magnetization Transfer in Magnetic Resonance Fingerprinting

Tom Hilbert^1,2,3, Tobias Kober^1,2,3, Tiejun Zhao⁴, Tobias Kai Block^5,6, Zidan Yu^5,6, Jean-Philippe Thiran³, Gunnar Krueger^2,3,7, Daniel K Sodickson^5,6, and Martijn Cloos^5,6

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Siemens Medical Solution USA, Pittsburgh, PA, United States, ⁵New York University School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York, NY, United States, ⁶Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ⁷Siemens Medical Solutions USA, Inc., Boston, MA, United States

Magnetic Resonance Fingerprinting (MRF) is a powerful technique for the quantification of relaxation parameters, and ideally provides correct estimates independent from the sequence used. In this work, we show that the quantification can be influenced by the pulse duration or, equivalently, the pulse bandwidth. This behavior, which we hypothesize to be related to magnetization transfer (MT) effects, is shown for the PnP-MRF sequence. We propose a first approach to encode MT effects in the MRF sequence and to model MT effects in the reconstruction, showing that this mitigates the bias in the resulting relaxation estimates.

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