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Abstract #0075

Clinically viable FAST-T2 based whole brain myelin water content mapping: T1 validation and initial MS lesion study

Thanh D. Nguyen1, Yihao Yao1, Pascal Spincemaille1, Eric Morris2, Susan A. Gauthier2, and Yi Wang1

1Radiology, Weill Cornell Medical College, New York, NY, United States, 2Neurology, Weill Cornell Medical College, New York, NY, United States

The objectives of this study were to validate the accuracy of FAST-T1 mapping required for myelin water content (MWC) mapping, and to demonstrate the feasibility of fast MWC mapping in MS patients. FAST-T1 provides whole brain T1 map in 3 min, which was in excellent agreement with that obtained with the reference IR-FSE method. MWC mapping in 20 MS patients showed a consistent increase in water content in MS lesions (10.7% on average), accompanied by 62.8% increase in T1 and 44.6% decrease in MWC when compared to the contralateral NAWM.

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