In the qBOLD technique, the accuracy of local deoxygenated blood volume and hemoglobin oxygen saturation (Yv) maps is potentially degraded due to high coupling of the two parameters in the model. As an alternative, the QUIXOTIC method measures local Yv by selectively capturing venular spins via T2-prepared velocity-selective-spin-labeling. However, CSF signals, if not suppressed, may impair accuracy of venular blood T2 estimation. In this work, extravascular R2’ and intravascular R2 mapping methods are interleaved to reduce estimation uncertainty in the qBOLD model while the accuracy of preliminary venular T2 estimates from the latter is further enhanced via phase-sensitive CSF suppression.
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