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Abstract #0088

Improved Muscle Microstructure Analysis with Diffusion Weighted Imaging and Advanced Tissue Modeling

Nagesh Adluru1, Richard Kijowski 2, and Fang Liu2

1Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison

Studies on musculoskeletal systems can benefit by quantitative mapping of the tissue microstructure. Parameters from traditional diffusion tensor imaging (DTI) may serve as bio-markers for assessing muscle fiber health. While these parameters are sensitive to changes of muscle fiber orientation, length and tension, they are non-specific to the changes of microstructure and microcomposition of muscle fibers. In this study, we proposed to use multi-shell diffusion weighted imaging acquisition with advanced diffusion and micro tissue modeling to improve in-vivo muscle fiber analysis and demonstrated the feasibility of applying these methods on in-vivo human thigh muscle imaging.

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