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Abstract #0093

Compressed Sensing accelerated time-resolved 3D phase contrast MRI of the lower leg muscles during active dorsi- and plantarflexion

Lukas M. Gottwald1, Valentina Mazzoli1,2,3, Eva S. Peper1, Qinwei Zhang1, Bram F. Coolen4, Pim van Ooij1, Gustav J. Strijkers4, and Aart J. Nederveen1

1Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Orthopaedic Research Lab, Radboud UMCN, Nijmegen, Netherlands, 4Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands

Time-resolved 3D phase-contrast MRI can be applied to quantify muscle contraction. 3D coverage with sufficient spatiotemporal resolution (~3x3x5mm3, 160ms) can only be achieved by interleaved acquisitions during many repetitions of a motion task, resulting in long scan times (>10min). In this study we have developed an accelerated protocol, using k-space undersampling and compressed-sensing reconstruction, which was applied on the lower leg of 4 volunteers performing a foot plantar-dorsal flexion motion task. Muscle velocities during the motion cycle of fully-sampled and accelerated protocols were compared. Acceleration was successful up to 6.4X with comparable velocities, which confirmed the benefit of this approach.

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