Abstract #0093

Compressed Sensing accelerated time-resolved 3D phase contrast MRI of the lower leg muscles during active dorsi- and plantarflexion

Lukas M. Gottwald¹, Valentina Mazzoli^1,2,3, Eva S. Peper¹, Qinwei Zhang¹, Bram F. Coolen⁴, Pim van Ooij¹, Gustav J. Strijkers⁴, and Aart J. Nederveen¹

¹Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ³Orthopaedic Research Lab, Radboud UMCN, Nijmegen, Netherlands, ⁴Department of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands

Time-resolved 3D phase-contrast MRI can be applied to quantify muscle contraction. 3D coverage with sufficient spatiotemporal resolution (~3x3x5mm³, 160ms) can only be achieved by interleaved acquisitions during many repetitions of a motion task, resulting in long scan times (>10min). In this study we have developed an accelerated protocol, using k-space undersampling and compressed-sensing reconstruction, which was applied on the lower leg of 4 volunteers performing a foot plantar-dorsal flexion motion task. Muscle velocities during the motion cycle of fully-sampled and accelerated protocols were compared. Acceleration was successful up to 6.4X with comparable velocities, which confirmed the benefit of this approach.

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