We describe measurement of skeletal muscle kinematics with a multiple echo diffusion tensor imaging (MEDITI) in clinical scanners. This approach allows characterization of the microstructural dynamics in healthy and diseased muscle. Combining the accelerated MEDITI directional encoding with a radial k-space trajectory and compressed sensing reconstruction allows spatially resolved DTI with a continuous temporal resolution of 16 s. Using an MR-compatible ergometer, post-exercise recovery of DTI metrics in calf muscle were quantified in a pilot cohort of 2 volunteers and 4 subjects with chronic exertional compartment syndrome (CECS). Results indicate anisotropic exercise response and recovery with kinetics differing from relaxation contrast.
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