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Abstract #0092

Dynamic Diffusion Tensor Imaging in Normal and Compartment Syndrome Calf Muscle with MEDITI

Eric Edward Sigmund1,2, Steven Hubert Baete1,2, Karan Patel1,3, Di Wang1,3, Ricardo Otazo1,2, Prodromos Parasoglou1,2, and Jenny Bencardino1

1Radiology, NYU Langone Medical Center, New York, NY, United States, 2Center for Advanced Imaging and Innovation (CAIIR), New York, NY, United States, 3NYU Tandon School of Engineering

We describe measurement of skeletal muscle kinematics with a multiple echo diffusion tensor imaging (MEDITI) in clinical scanners. This approach allows characterization of the microstructural dynamics in healthy and diseased muscle. Combining the accelerated MEDITI directional encoding with a radial k-space trajectory and compressed sensing reconstruction allows spatially resolved DTI with a continuous temporal resolution of 16 s. Using an MR-compatible ergometer, post-exercise recovery of DTI metrics in calf muscle were quantified in a pilot cohort of 2 volunteers and 4 subjects with chronic exertional compartment syndrome (CECS). Results indicate anisotropic exercise response and recovery with kinetics differing from relaxation contrast.

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