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Abstract #0097

Amide proton transfer magnetic resonance imaging of uterine endometrial cancer: Association with histologic grade

Yukihisa Takayama1, Akihiro Nishie2, Osamu Togao2, Yoshiki Asayama2, Kousei Ishigami2, Yasuhiro Ushijima2, Daisuke Okamoto2, Nobuhiro Fujita2, Kenzo Sonoda3, Jochen Keupp4, and Hiroshi Honda2

1Department of Radiology Informatics and Network, Kyushu University, Fukuoka, Japan, 2Department of Clinical Radiology, Kyushu University, 3Department of Gynecology & Obstetrics, Kyushu University, 4Philips Research

The histologic grade of endometrioid adenocarcinoma (EMCA) is one of the important factors in choosing a treatment plan. Currently, needle biopsy or surgical resection is necessary to diagnose the histological grade; a less invasive procedure is strongly desired. In this study, we evaluated the utility of amide proton transfer (APT) imaging in estimating the histologic grade of EMCA. APT signal intensities (SIs) of EMCA increased in accordance with the progression of histologic grade. APT SIs of high-grade EMCA were significantly higher than those of low-grade EMCA. APT imaging has potential as a biomarker for histologic grade of EMCA.

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