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Abstract #0098

The prognostic power of early and late phase DCE-MRI parameters in locally advanced cervix cancer.

Kjersti Vassmo Lund1,2, Trude Golimo Simonsen2, Gunnar B. Kristensen3,4,5, and Einar K. Rofstad2

1Dept og Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 2Dept. of Radiation Biology, Institute of cancer Research, Oslo University Hospital, Oslo, Norway, 3Dept. of Gynecological Cancer, Oslo University Hospital, Oslo, Norway, 4Institute for Cancer Genetics and Informatics, Oslo University Hospital, Oslo, Norway, 5Institute for Clinical Medicine, University of Oslo, Oslo, Norway

DCE-MRI can provide prognostic information on locally advanced cervix carcinomas. Most studies have emphasis on the early phase of the Signal Intensity Time Curve (SITC). The purpose of this study was to explore the prognostic value of the late phase of the SITC and to reveal any added value to that of parameters from the early phase. Both the early phase parameter LETV and the late phase parameter TVIS was associated with overall survival. The association was independent of clinical factors like tumor volume, FIGO stage and lymph node status. TVIS did not provide any added prognostic value to LETV.

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