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Abstract #0099

Histogram analysis of intravoxel incoherent motion MRI in predicting chemoradiotherapy response in cervical cancer

Jose Angelo Udal Perucho1, Elaine Yuen Phin Lee1, Wing Chi Lawrence Chan2, Nanjie Gong3, and Queenie Chan4

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department  of  Health  Technology  and  Informatics, The Hong Kong Polytechnic University, Hong Kong, 3University of California, Berkeley, CA, United States, 4Philips Healthcare, Hong Kong, Hong Kong

Histogram analysis of intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DWI) could be a promising quantitative approach in predicting tumour response to chemoradiotherapy (CRT) in cervical cancer. We retrospectively studied twenty-five patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of treatment. We observed that histogram skewness of true diffusion coefficient (D) prior to treatment and that a large increase in the 90th percentile of D following CRT were predictive of better CRT response.

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