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Abstract #0108

Detecting orientation selective deep brain stimulation using BOLD fMRI

Lauri J Lehto1, Julia P Slopsema2, Matthew D Johnson2, Artem Shatillo3, Benjamin A Teplitzky2, Lynn Utecht1, Gregor Adriany1, Silvia Mangia1, Alejandra Sierra3, Walter C Low4, Olli Gröhn1,3, and Shalom Michaeli1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 3A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 4Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

Spatial selectivity is of high importance for Deep Brain Stimulation (DBS). Here we used BOLD fMRI to demonstrate for the first time that axon-orientation selective stimulation can be achieved in the rat’s corpus callosum by steering the stimulus phase of the independently driven channels in a tripolar DBS electrode. Pronounced angular dependence of the BOLD fMRI on the orientation of electric field gradient was detected. As expected based on simulations, the maximal (or minimal) BOLD response was observed when the induced dipole field was parallel (or perpendicular) to the axonal tract, respectively.

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