Abstract #0108

Detecting orientation selective deep brain stimulation using BOLD fMRI

Lauri J Lehto¹, Julia P Slopsema², Matthew D Johnson², Artem Shatillo³, Benjamin A Teplitzky², Lynn Utecht¹, Gregor Adriany¹, Silvia Mangia¹, Alejandra Sierra³, Walter C Low⁴, Olli Gröhn^1,3, and Shalom Michaeli¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, ³A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ⁴Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States

Spatial selectivity is of high importance for Deep Brain Stimulation (DBS). Here we used BOLD fMRI to demonstrate for the first time that axon-orientation selective stimulation can be achieved in the rat’s corpus callosum by steering the stimulus phase of the independently driven channels in a tripolar DBS electrode. Pronounced angular dependence of the BOLD fMRI on the orientation of electric field gradient was detected. As expected based on simulations, the maximal (or minimal) BOLD response was observed when the induced dipole field was parallel (or perpendicular) to the axonal tract, respectively.

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