Meeting Banner
Abstract #0109

Functional MRI evaluation of a novel approach to neuromodulation: Targeted delivery of GABA via focused ultrasound-mediated disruption of the blood-brain barrier

Nick Todd1, Tao Sun1, Yongzhi Zhang1, Chanikarn Power1, Chanikarn Power1, Michael Arcaro2, Sam Patz1, Margaret Livingstone2, and Nathan McDannold1

1Brigham and Women's Hospital, Boston, MA, United States, 2Department of Neurobiology, Harvard Medical School, Boston, MA, United States

Here we present a novel approach to non-invasive neuromodulation that affects neuronal activity by delivering neurotransmitter chemicals to targeted areas of the brain. This is achieved by using focused ultrasound to transiently open the blood-brain barrier in a targeted brain region such that a systemically injected neuroactive chemical such as GABA or glutamate will leak out of the vessels and into the brain parenchyma only at the intended site. We demonstrate the proof of concept in a rodent model by delivering GABA to the somatosensory cortex to suppress activation from hindpaw stimulation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here