Within this work an approach based on the temperature dependence of the proton resonance frequency (PRF) of water and methylene bound protons is followed to monitor in-vivo thermogenesis in the interscapular brown adipose tissue (iBAT) of mice. Measuring the change in chemical shift difference of water and fat rather than water alone, known problems of PRF-based temperature measurements such as magnetic field drift and the temperature dependence of magnetic susceptibility are circumvented. The study determines the temperature coefficient in ex-vivo iBAT tissue extracts and presents the application of the technique in measuring norepinephrine stimulated in-vivo iBAT thermogenesis.
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