Pancreatic beta cells secrete insulin to maintain normal blood glucose levels, and the integrity and function of pancreatic beta cells have been found to be compromised in Type-1 and Type-2 diabetes. Therefore, non-invasive beta cell function measurements may provide valuable information for improving diabetes diagnostics and disease management. Currently available diabetes assays lack functional information and spatial identification of properly functioning beta cells. In this work, we introduce a new assay to assess the function and identify functional beta cells in vivo in the non-human primate pancreas non-invasively with MRI using a Gd-based zinc sensor as contrast agent.
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