Abstract #0117

Free-breathing R2* Characterization of the Placenta During Normal Early Gestation Using a Multiecho 3D Stack-of-Radial Technique

Tess Armstrong^1,2, Dapeng Liu¹, Thomas Martin^1,2, Alto Stemmer³, Yutaka Natsuaki⁴, Sherin U. Devaskar⁵, Carla Janzen⁶, Teresa Chanlaw⁵, Rinat Masamed¹, Daniel Margolis⁷, Kyunghyun Sung^1,2, and Holden H. Wu^1,2

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Siemens Healthcare, Los Angeles, CA, United States, ⁵Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁶Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ⁷Radiology, Weill Cornell Medical College, New York, NY, United States

Abnormal placental vascular development leads to ischemic-hypoxia thereby causing fetal growth restriction, preterm labor, and spontaneous abortion. Multiecho Cartesian MRI can characterize placental hypoxia by quantifying R2*, but is susceptible to motion artifacts. We have developed a new free-breathing (FB) multiecho R2* quantification technique using 3D stack-of-radial imaging (Radial). In n=16 subjects as part of an IRB-approved study, we observed an R2* range of 5 – 30s^-1 at 3 T using the new FB Radial technique in the placenta during early normal gestation. Our new technique and the measured normative range of R2* may improve management of pregnancies with placental ischemic-hypoxia.

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