Abstract #0118

Respiratory $$$\alpha$$$-mapping of cystic fibrosis at 1.5T

Orso Pusterla^1,2, Grzegorz Bauman^1,2, Sylvia Nyilas³, Philipp Madörin¹, Bernd Jung⁴, Michael Ith⁴, Enno Stranzinger⁴, Urs Frey⁵, Philipp Latzin³, and Oliver Bieri^1,2

¹Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland, ⁴University Institute for Diagnostic, Interventional and Pediatric Radiology, Bern University Hospital, Bern, Switzerland, ⁵Department of Pediatric Pneumology, University Children's Hospital Basel, Basel, Switzerland

Respiratory $$$\alpha$$$-mapping is based on native 1H multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) breath-hold imaging of the lung and provides whole lung isotropic pulmonary ventilation-related information. In this work, respiratory $$$\alpha$$$-mapping is evaluated in pediatric patients with cystic fibrosis (CF) and compared to functional lung parameters from nitrogen multiple-breath washout (N₂-MBW). The percentage of respiratory $$$\alpha$$$-impairments measured with $$$\alpha$$$-mapping is strongly correlated with the lung clearance index (LCI), a parameter for global ventilation inhomogeneity.

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