Using a recently developed joint intravoxel incoherent motion (IVIM)- diffusion tensor imaging (DTI) protocol for kidney evaluation, we present reproducibility analysis of its metrics in normal volunteers, as well as pilot assessments in several patients with renal masses prior to surgery. Reproducibility analysis indicates a subset of robust parameters, including structural and microcirculation markers in both cortex and medulla, for clinical application. Preliminary results in renal mass patients suggest multifactorial differences from controls, supporting the need for advanced diffusion characterization in assessing renal functional reserve.
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