Although small arterial system plays a key role in delivering oxygen and glucose to brain tissue, the in vivo detection is still challenging. Using a low dose of ultra-small-superparamagnetic-iron-oxide (USPIO) contrast agent, it will induce susceptibility contrast in the arterial blood, which enhances the small arteries visibility on susceptibility weighted imaging. This study has demonstrated its feasibility in human brain. Such technique has potential to unveil underlyingmicrovascular abnormalities in neurovascular diseases that cannot be done in vivo with any other conventional method in use today.
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