Abstract #0144

T2-relaxation-under-spin-tagging (TRUST) and Arterial Spin Labeling MRI elucidate discrepant hemo-metabolic mechanisms underlying elevated oxygen extraction fraction (OEF) in moyamoya and sickle cell anemia (SCA) patients

Jennifer M Watchmaker¹, Meher R Juttukonda¹, Larry T Davis¹, Allison O Scott¹, Carlos C Faraco¹, Melissa C Gindville², Lori C Jordan², Petrice M Cogswell¹, Angela L Jefferson³, Howard S Kirshner⁴, and Manus J Donahue^1,4,5

¹Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Pediatrics, Division of Pediatric Neurology, Vanderbilt University Medical Center, ³Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Neurology, Vanderbilt University Medical Center, ⁵Department of Psychiatry, Vanderbilt University Medical Center

T₂-relaxation-under-spin-tagging (TRUST-MRI) was performed in patients with intracranial stenosis due to moyamoya for determination of whole-brain oxygen extraction fraction (OEF). Elevated OEF was observed in this group compared to controls. In¹⁵O PET studies in individuals with intracranial stenosis, it has been shown that OEF increases regionally when cerebral blood volume (CBV) is inadequate to maintain cerebral blood flow (CBF) over a normal range, and importantly that regionally elevated OEF and CBV may be prognostic for recurrent stroke risk. This work has motivated the development and application of TRUST-MRI for use in patients with intracranial stenosis at risk for stroke.

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