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Abstract #0145

4D MR Angiography with Pseudo-Continuous Arterial Spin Labelling Combined with CENTRA-Keyhole (4D-PACK): Visualization of Distal Cerebral Arteries in Moyamoya Disease

Osamu Togao1, Akio Hiwatashi1, Makoto Obara2, Koji Yamashita1, Ryotaro Kamei1, and Hiroshi Honda1

1Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Philips Electronics Japan, Tokyo, Japan

In the present study, we demonstrated the clinical utility of 4D-MR angiography with pCASL combined with CENTRA-keyhole (4D-PACK) in Moyamoya disease by comparing with a well-established pulsed ASL-based 4D-MRA called contrast inherent inflow enhanced multi-phase angiography (CINEMA). 4D-PACK provided higher CNRs than CINEMA in distal MCA branches in later phases indicating that 4D-PACK enables better visualizations of distal cerebral arteries supplied by collaterals vessels during a long transit time. This could be due to higher flow signal obtained with pCASL and less saturation effect after labeling. 4D-PACK can be a non-invasive clinical tool in assessing hemodynamics in Moyamoya disease.

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