Abstract #0147

Analysis of cerebrovascular watershed areas in patients with high-grade carotid artery stenosis using DSC-based time-to-peak maps

Vanessa Griese¹, Stephan Kaczmarz¹, Anne Kluge^1,2, Kim van de Ven³, Michael Helle⁴, Hendrik Kooijman-Kurfuerst⁴, Claus Zimmer¹, Christian Sorg ^1,5, Jens Göttler¹, and Christine Preibisch^1,5,6

¹Neuroradiology, Technical University of Munich, Munich, Germany, ²Radioonkology and Radiotherapy, Charité Berlin, Berlin, Germany, ³Philips Healthcare, Best, Netherlands, ⁴Philips Research, Hamburg, Germany, ⁵TUM Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, Germany, ⁶Neurology, Technical University of Munich, Munich, Germany

Internal carotid artery stenosis (ICAS) is one of the leading causes for thromboembolic and hemodynamic cerebral infarction. Here, we present data from an ongoing clinical MRI-study in patients with asymptomatic, high-grade ICAS and healthy controls. Our major aim was to establish a method to delineate individual watershed areas in patients and controls using MRI-based dynamic susceptibility contrast (DSC) time-to-peak (TTP) maps, also including the anatomical information of magnetic resonance angiography (MRA) to define individual vascular territories. Watershed areas were enlarged and shifted in many of the vascular territories of stenosed carotid arteries, being verified by ss-pCASL in a subgroup.

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