Meeting Banner
Abstract #0149

One-sided hypoperfusion is associated with contralateral attention deficits in asymptomatic high-grade carotid stenosis patients.

Jens Goettler1, Stephan Kaczmarz1, Rachel Nuttall1, Vanessa Griese1, Hendrik Kooijman2, Michael Helle2, Kim van de Ven3, Claus Zimmer1, Kathrin Finke4, Christian Sorg1, and Christine Preibisch1

1Department of Neuroradiology, Technische Universität München, Munich, Germany, 2Philips Healthcare, Hamburg, Germany, 3Philips Healthcare, Best, Netherlands, 4Neuro-cognitive Psychology Unit, Department Psychologie, Ludwig-Maximillians-Universität, Munich, Germany

Patients with clinically asymptomatic, high-grade internal carotid artery stenosis (ICAS) often show cognitive impairments, such as memory dysfunction and attention deficits. However, it is still unclear whether these symptoms are caused by potentially reversible cerebral hypoperfusion or rather by a general unchangeable vascular damage. Here, 17 patients with one-sided high-grade, asymptomatic ICAS and 26 age-matched healthy controls underwent an MRI scan, including pCASL to assess brain perfusion, and a computer-based visual attention test. Patients show distinct unilateral cerebral hypoperfusion being significantly associated with contralateral attention deficits. Data indicate that chronic cerebral hypoperfusion in high-grade ICAS impairs cognitive function.

This abstract and the presentation materials are available to members only; a login is required.

Join Here