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Abstract #0150

Saccular intracranial aneurysm wall permeability and shear stress distribution: a further insight into rupture pathogenesis

Xian Liu1, Yu Chen1, Haikun Qi1, Peng Liu2, Yunduo Li1, Xiaole Wang1, Le He1, Qiang Zhang1, Zhensen Chen1, Rui Li1, Youxiang Li2, Chun Yuan3, and Huijun Chen1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, People's Republic of China, 2Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China, 3Department of Radiology, University of Washington, Seattle, WA, United States

The purpose of this study is to explore the relationship between aneurysm wall permeability and the hemodynamic conditions of intracranial aneurysm (IA). The results showed that hot spot of IA wall permeability was spatially related with significantly lower wall shear stress magnitude and higher oscillatory shear index, which suggests the pathology of IA might be an interaction of both factors, and IA wall permeability could be a potential method for IA rupture risk assessment.

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