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Abstract #0160

Tonotopic mapping in the in vivo mouse via high resolution fMRI

Guilherme Blazquez Freches1, Cristina Chavarrias1, and Noam Shemesh1

1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

The rodent auditory system has been a popular research subject for electrophysiological studies for its complexity, fine tuning and adaptability. More recently, some studies on auditory Functional Magnetic Resonance Imaging (fMRI) in rats have surfaced, aiming to unravel this system’s intricacies by capturing whole brain activity noninvasively. Auditory mapping in the mouse could be highly valuable given its importance vis-à-vis transgenic models and optogenetics. This study provides the first tonotopic mapping in the in vivo mouse via high resolution fMRI. We demonstrate robust activation in the auditory pathway, and specific tonotopy in several prominent regions along the pathway.

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