Abstract #0166

Effects of 3-MPA on in vivo hepatic metabolism of hyperpolarized [1-13C] pyruvate

Emine Can¹, Hikari A.I. Yoshihara^1,2, Jessica A.M. Bastiaansen^1,2, Rolf Gruetter^3,4, and Arnaud Comment¹

¹Institute of Physics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Division of Cardiology, University Hospital Lausanne (CHUV), Lausanne, Switzerland, ³Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Department of Radiology, University of Lausanne (UNIL), Lausanne, Switzerland

Ex vivo and in vivo studies on liver metabolism using hyperpolarized [1-¹³C]pyruvate report do not agree on whether hyperpolarized bicarbonate metabolite production results from pyruvate oxidation or gluconeogenesis. This study tested the ability of hyperpolarized [1-¹³C]pyruvate to probe gluconeogenesis in the liver of intact rats. While conversion to hyperpolarized bicarbonate was detected in the liver of fasted rats, treatment with the phosphoenolpyruvate carboxykinase inhibitor 3-mercaptopicolinc acid resulted in 7-fold lower levels. This result supports the notion that hepatic gluconeogenic metabolism can indeed be directly probed in vivo with hyperpolarized pyruvate.

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