Abstract #0165

Metabolic imaging of neuroinflammation in the cuprizone mouse model for Multiple Sclerosis using hyperpolarized [1-13C] pyruvate

Caroline Guglielmetti^1,2,3, Chloe Najac², Annemie Van der Linden³, Sabrina Ronen^2,4, and Myriam Chaumeil^1,2

¹Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, ²Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Bio-Imaging Lab, Department Pharmaceutical, Veterinary and Biomedical Sciences, University of Antwerp, Antwerp, Belgium, ⁴Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, San Francisco, CA, United States

Our study demonstrates that metabolic imaging of hyperpolarized [1-¹³C] pyruvate can detect increased hyperpolarized lactate production in vivo in highly inflammatory white matter lesions in a preclinical model of Multiple Sclerosis. Increased lactate production was associated with the presence of pro-inflammatory macrophages upregulating pyruvate dehydrogenase kinase 1, as well as regional inhibition of pyruvate dehydrogenase, providing a likely mechanism for a decrease subsequent flux of pyruvate towards the Krebs cycle. Our study demonstrates that metabolic imaging of hyperpolarized [1-¹³C] pyruvate has high potential for in-vivo detection and monitoring of neuroinflammation levels during demyelination and remyelination.

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