Abstract #0168

Hyperpolarized 13C Magnetic Resonance Evaluation of Renal Ischemia Reperfusion Injury in a Murine Model

Celine Baligand¹, Hecong Qin², Aisha True-Yasaki², Jeremy W. Gordon², Cornelius VonMorze², Justin DeLos Santos², Joy P. Walker³, David M. Wilson², Robert L. Raffai³, John Kurhanewicz², David H. Lovett⁴, and Zhen J. Wang²

¹Department of Radiology, Leiden University Medical Center, C.J. Gorter Center for High-field MRI, Leiden, Netherlands, ²Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ³Department of Surgery, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Medicine, University of California San Francisco, San Francisco, CA, United States

Persistent oxidative stress and mitochondrial dysfunction have been implicated across diverse forms of acute kidney injury and in the transition to chronic kidney disease. We show that HP ¹³C metabolic MR can be used to noninvasively assess the altered renal redox capacity and mitochondrial PDH activity following ischemic reperfusion injury. Such an imaging approach can potentially enhance the prediction and monitoring of progressive kidney injury.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.