Hyperpolarized [13C] urea perfusion imaging using velocity-selective excitation is qualitatively and semi-quantitatively compared with clinically used [1H] Gadolinium first-pass perfusion imaging in healthy pigs. Higher contrast-to-noise ratios and comparable sensitivity for semi-quantitative perfusion measures over myocardial sectors can be achieved with [13C] urea. Arterial input sampling in the ascending aorta using a second imaging slice with conventional excitation is proposed. Feasibility of accurate absolute myocardial blood flow quantification using [13C] urea is demonstrated.
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