Abstract #0171

Imaging c-Myc: Identification of metabolic phenotypes using MRSI of hyperpolarised [1-13C]pyruvate to [1-13C]lactate flux in glioblastoma patient-derived orthotopic xenografts.

Richard Mair^1,2, Alan Wright¹, Colin Watts², and Kevin Brindle¹

¹CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ²Division of Neurosurgery, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom

Heterogeneity at both a genomic and phenotypic level is extant within glioblastoma. We hypothesised that imaging of the flux from hyperpolarised [1-13C]pyruvate to [1-13C]lactate may inform upon this heterogeneity. We used patient derived orthotopic xenograft cohorts to identify differential lactate labelling and have related this to both glycolytic enzyme and c-Myc expression.

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