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Abstract #0171

Imaging c-Myc: Identification of metabolic phenotypes using MRSI of hyperpolarised [1-13C]pyruvate to [1-13C]lactate flux in glioblastoma patient-derived orthotopic xenografts.

Richard Mair1,2, Alan Wright1, Colin Watts2, and Kevin Brindle1

1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Division of Neurosurgery, Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom

Heterogeneity at both a genomic and phenotypic level is extant within glioblastoma. We hypothesised that imaging of the flux from hyperpolarised [1-13C]pyruvate to [1-13C]lactate may inform upon this heterogeneity. We used patient derived orthotopic xenograft cohorts to identify differential lactate labelling and have related this to both glycolytic enzyme and c-Myc expression.

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