Abstract #0173

Kt-dSTEAM: high resolution diffusion-weighted imaging of the ex vivo human brain using B1+ homogenized STEAM at 9.4T

Francisco J. Fritz¹, Desmond H Y Tse¹, Shubarthi Sengupta¹, Tim K. Loderhose¹, Bram Kraaijeveld¹, Svenja Caspers², Benedikt A. Poser¹, and Alard Roebroeck¹

¹Cognitive Neuroscience Department, Maastricht University, Maastricht, Netherlands, ²Institut für Neurowissenschaften und Medizin (INM-1), Forschungszentrum Jülich, Jülich, Germany

The investigation of entire human brains post mortem with diffusion MRI is an important research tool. However, the achievable resolutions and contrast are limited by gradient performance, RF-field inhomogeneity and strongly reduced T₂ and diffusivity. Here, a diffusion-weighted STEAM sequence was modified to enable the use of k_T-points B₁+ homogenization and 3D segmented EPI readout. The resulting k_T-dSTEAM sequence allows for high resolution (1000μm, 500μm and 400μm isotropic) diffusion-weighted imaging the entire human brain with homogenous contrast at 9.4T.

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