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Abstract #0173

Kt-dSTEAM: high resolution diffusion-weighted imaging of the ex vivo human brain using B1+ homogenized STEAM at 9.4T

Francisco J. Fritz1, Desmond H Y Tse1, Shubarthi Sengupta1, Tim K. Loderhose1, Bram Kraaijeveld1, Svenja Caspers2, Benedikt A. Poser1, and Alard Roebroeck1

1Cognitive Neuroscience Department, Maastricht University, Maastricht, Netherlands, 2Institut für Neurowissenschaften und Medizin (INM-1), Forschungszentrum Jülich, Jülich, Germany

The investigation of entire human brains post mortem with diffusion MRI is an important research tool. However, the achievable resolutions and contrast are limited by gradient performance, RF-field inhomogeneity and strongly reduced T2 and diffusivity. Here, a diffusion-weighted STEAM sequence was modified to enable the use of kT-points B1+ homogenization and 3D segmented EPI readout. The resulting kT-dSTEAM sequence allows for high resolution (1000μm, 500μm and 400μm isotropic) diffusion-weighted imaging the entire human brain with homogenous contrast at 9.4T.

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