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Abstract #0199

B1+ inhomogeneity mitigation in CEST using parallel transmission: pTxCEST

Nuno André da Silva1, Desmond H. Y. Tse2, Benedikt A Poser2, and N Jon Shah1,3,4

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, 2Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, 4Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

To demonstrate the benefits from the increased spectral bandwidth at ultra-high field (UHF) by using parallel transmission (pTx) to mitigate flip-angle inhomogeneity in chemical exchange saturation transfer (CEST) imaging. A pTx basis pulse is homogenised by magnitude least-squares (MLS) optimisation and expanded to form a frequency-selective saturation pulse for CEST. The pTx saturation pulse was validated by both Bloch-McConnell simulation and in vivo imaging at 7T. Improved homogeneity in contrasts and relaxation-compensated CEST metrics were observed in our in vivo data when the pTx saturation pulse was used instead of the standard CP-mode Gaussian pulse.

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