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Abstract #0200

Understanding concomitant effects between CEST and ASL contrast.

Francisco Torrealdea1,2, Marilena Rega3, Mohamed Tachrount1, Magdalena Sokolska4, and Xavier Golay1

1Institute of Neurology, UCL, London, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Institute of Nuclear Medicine, UCLH, London, United Kingdom, 4Medical Physics and Biomedical Engineering, UCLH, London

This study aims to assess the relationship between brain perfusion and CEST measurements. For this purpose, an oxygen-carbogen challenge experiment was designed in order to compare CEST measurements of the rat brain in low and high perfusion conditions.

Comparison of the CEST with CBF measurement show strong correlation (p<0.005 with Spearman Rho=0.976). From the results of the study it is notable that blood perfusion is a strong modulator of the observed CEST signal in the rat brain.

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