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Abstract #0202

D2O Perfusion MRI of Brain Tumor on a Mouse Model: A Preliminary Study

Pei-Lun Yu1, Sheng-Min Huang1, Cheng-He Li1, Sheng-Yan Wu 1, Chi-Shiun Chiang1, Kung-Chu Ho2, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Recently, deuterium oxide (D2O) has been proposed as an alternative contrast agent on rodent brain perfusion by monitoring the attenuation of 1H signal. Since D2O is a highly diffusible contrast agent, the revealed information of Gd chelates and D2O are different. In this study, we aimed to re-investigate the perfusion information carried by D2O with advanced spatial resolution. We speculated that D2O slowly diffused into tumor area and continuously exchanged with tissue water until a balanced concentration. Inside the tumor region, the heterogeneity shown by D2O and Gd-DTPA are somewhat different.

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