Perfusion weighted imaging (PWI) using dynamic susceptibility contrast (DSC) imaging is a widely used technique in tumour imaging. The use of multi-echo DSC, gradient and spin echo (GESE), allows one to obtain vasculature information. However, trade-off between number of echoes, spatial resolution and brain coverage is required. In this work, the use of EPI with keyhole (EPIK) combined with multi-band is proposed to obtain a whole brain multi-echo GESE-DSC in clinically relevant acquisition times. The method was applied in a cohort of brain tumour patients in a MR-PET scanner enabling localisation of the tumour based on metabolic information from PET.