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Abstract #0206

Full Brain Vasculature Analysis using Gradient/Spin-Echo Multi-band EPIK: Tumour Evaluation with MR-PET

Nuno André da Silva1, N Jon Shah1,2,3, Rute Lopes1,4, Ezequiel Farrher1, and Seong Dae Yun1

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, 3Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia, 4Institute of Biomedical Engineering and Biophysics, Science Faculty of University of Lisbon, Lisbon, Portugal

Perfusion weighted imaging (PWI) using dynamic susceptibility contrast (DSC) imaging is a widely used technique in tumour imaging. The use of multi-echo DSC, gradient and spin echo (GESE), allows one to obtain vasculature information. However, trade-off between number of echoes, spatial resolution and brain coverage is required. In this work, the use of EPI with keyhole (EPIK) combined with multi-band is proposed to obtain a whole brain multi-echo GESE-DSC in clinically relevant acquisition times. The method was applied in a cohort of brain tumour patients in a MR-PET scanner enabling localisation of the tumour based on metabolic information from PET.

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