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Abstract #0207

Comparison of Ferumoxytol based Cerebral Blood Volume estimates using Multi-Echo T2* and Ultrashort Echo Time T1 Imaging

Leonardo Rivera Rivera1, Tilman Schubert2, Patrick A Turski2, and Kevin M Johnson1

1Dept. of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Dept. of Radiology, University of Wisconsin-Madison, Madison, WI, United States

Intracranial vascularity is modified in a wide array of diseases including cancer, various forms of dementia, and stroke. Steady state imaging with Ferumoxytol provides unique opportunities to estimate cerebral blood volume (CBV). In this work, we investigate the correlation between relaxometry changes measured utilizing ultrashort echo time variable flip angle (UTE-VFA) R1 and a multi-echo R2* approaches. Initial results from 8 healthy volunteers shows a high degree of correlation of R1 with R2* measures and improved performance in and around vessels. This, and opportunities to probe disease induced disagreements, suggests potential value in combined R1 and R2* measures.

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