Abstract #0219

Investigation of outer and inner cerebellar MTR abnormalities in different MS clinical subtypes

Rebecca Sara Samson¹, Manuel J Cardoso^2,3, Nils Muhlert^1,4, Varun Sethi^1,5, Özgür Yaldizli^1,6, Maria A Ron¹, Ferran Prados ^1,2, Sebastian Ourselin^2,3, David H Miller^1,7, Claudia A M Gandini Wheeler-Kingshott^1,8,9, and Declan T Chard^1,7

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College London, London, United Kingdom, ⁴Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, ⁵Department of Neurology, Nottingham University Hospitals, Nottingham, United Kingdom, ⁶Department of Neurology, University Hospital Basel, Basel, Switzerland, ⁷National Institute for Health Research (NIHR) University College London Hospitals Biomedical Research Centre, United Kingdom, ⁸Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁹Brain MRI 3T Center, C. Mondino National Neurological Institute, Pavia, Italy

Histopathology has demonstrated extensive grey matter (GM) damage in MS, and an association with meningeal inflammatory factors has previously been suggested. We applied a method to subdivide the cerebellar GM (CGM) into inner and outer regions, and investigated for magnetization transfer ratio (CGM-MTR) abnormalities in MS subtypes compared to healthy controls (HC). Outer was lower than inner CGM-MTR in all groups including HC. Outer and inner CGM-MTR reductions were observed in progressive MS subtypes. Stronger correlations of outer than inner CGM-MTR with clinical scores were observed, suggesting that outer CGM-MTR may reflect more clinically relevant pathology, particularly in progressive MS.

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