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Abstract #0220

High Spatial Resolution Mapping of Trans-Capillary Water Exchange in Progressive Multiple Sclerosis

Ian Tagge1, Manoj Sammi1, Rebecca Spain2, Dennis Bourdette2, Randy West2, John Grinstead1,3, Katherine Powers1, Xin Li1, Charles Springer1, and William Rooney1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Neurology, Oregon Health & Science University, Portland, OR, United States, 3Siemens Medical Solutions, Portland, OR

DCE-MRI data were acquired from 14 healthy control (HC) and 16 secondary progressive multiple sclerosis subjects on a 7T MRI instrument to investigate difference in brain blood vessel properties. The Shutter-Speed Paradigm was used to map blood volume fraction and trans-capillary water exchange kinetics. Our finding suggest abnormalities in brain blood vessel properties suggestive of impaired metabolism in secondary progressive MS.

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