Abstract #0220

High Spatial Resolution Mapping of Trans-Capillary Water Exchange in Progressive Multiple Sclerosis

Ian Tagge¹, Manoj Sammi¹, Rebecca Spain², Dennis Bourdette², Randy West², John Grinstead^1,3, Katherine Powers¹, Xin Li¹, Charles Springer¹, and William Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Neurology, Oregon Health & Science University, Portland, OR, United States, ³Siemens Medical Solutions, Portland, OR

DCE-MRI data were acquired from 14 healthy control (HC) and 16 secondary progressive multiple sclerosis subjects on a 7T MRI instrument to investigate difference in brain blood vessel properties. The Shutter-Speed Paradigm was used to map blood volume fraction and trans-capillary water exchange kinetics. Our finding suggest abnormalities in brain blood vessel properties suggestive of impaired metabolism in secondary progressive MS.

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