Abstract #0221

Improving white matter lesion conspicuity in multiple sclerosis using patient-specific optimization of 3D FLAIR

Refaat E Gabr¹, Amol S Pednekar², Koushik A Govindarajan¹, Xiaojun Sun¹, Roy F Riascos¹, María G Ramírez¹, Khader M Hasan¹, John A Lincoln³, Flavia M Nelson³, Jerry S Wolinsky³, and Ponnada A Narayana¹

¹Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States, ²Philips Healthcare, Cleveland, OH, United States, ³Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States

Fluid-attenuated inversion recovery (FLAIR) imaging is widely used in multiple sclerosis (MS) scan protocols for its good lesion to tissue contrast. Optimization of 3D FLAIR acquisition parameters for the individual patient could further improve lesion conspicuity. In this work, tissue contrast between lesions and white matter for 3D FLAIR was optimized in the same scan session based on fast measurement of the relaxation times and proton density. Results on 16 MS patients show ~30% improved lesion contrast with the patient-specific acquisition parameters compared to the fixed-parameter 3D FLAIR sequence.

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