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Abstract #0247

CEST fMRI at ultra-high magnetic field

Tangi Roussel1, Lucio Frydman2, Denis Le Bihan1, and Luisa Ciobanu1

1NeuroSpin, Commisariat à l'Energie Atomique et aux Energies Alternatives, Gif-sur-Yvette, France, 2Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel

BOLD indirectly measures brain activity based on neurovascular coupling, a reporter which is naturally poor in both its spatial and temporal resolutions. Emerging methods involving spectroscopy (fMRS) and diffusion fMRI suggest that metabolic and structural modifications are taking place in the activated cells. In this paper, we introduce Chemical Exchange Saturation Transfer (CEST)-weighted fMRI as a new method to explore changes in rat brain activation at 17.2T. Monte Carlo simulations were performed to optimize the acquisition and processing methods. Experimentally, CEST-weighted fMRI activation maps showed negative contrast at +1.2ppm most likely originating from changes in the glucose metabolism.

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